GITR Antibodies in Cancer: Not Ready for Prime Time
Tatiana Hernández‐Guerrero, Víctor Moreno
Abstract
Glucocorticoid-induced TNF receptor (TNFR)-related protein (GITR) agonistic antibodies are expected to increase the antitumor response mainly by reducing the effect of Foxp3+ T-regulatory cells. TRX-518 is a novel GITR agonist that has shown good pharmacodynamic activity by depleting regulatory T cells (Tregs) in preclinical models, with limited clinical activity demonstrated in patients with advanced solid tumors. See related article by Davar et al., p. 3990.
Topics & Concepts
AntibodyPharmacodynamicsCancerAgonistFOXP3MedicineCancer researchPharmacologyImmunologyImmune systemReceptorInternal medicinePharmacokineticsImmunotherapy and Immune ResponsesT-cell and B-cell ImmunologyImmune Cell Function and Interaction