Characteristics and mechanisms of T‐cell senescence: A potential target for cancer immunotherapy
Han Wu, Junru Li, Zhen Zhang, Yi Zhang
Abstract
Immunosenescence, the aging of the immune system, leads to functional deficiencies, particularly in T cells, which undergo significant changes. While numerous studies have investigated age-related T-cell phenotypes in healthy aging, senescent T cells have also been observed in younger populations during pathological conditions like cancer. This review summarizes the recent advancements in age-associated alterations and markers of T cells, mechanisms, and the relationship between senescent T cells and the tumor microenvironment. We also discuss potential strategies for targeting senescent T cells to prevent age-related diseases and enhance tumor immunotherapy efficacy.
Topics & Concepts
ImmunosenescenceBiologySenescenceImmunotherapyImmune systemPhenotypeImmunologyCancerPathologicalTumor microenvironmentCancer immunotherapyCellular senescenceT cellCancer researchMedicineCell biologyPathologyGeneticsGeneImmune Cell Function and InteractionT-cell and B-cell ImmunologyCytomegalovirus and herpesvirus research