Iridium Catalysed Asymmetric Allylic Substitution Reaction of Indolizine Derivatives
Jiamin Lu, Meifang Wang, Ruigang Xu, Haizhou Sun, Xuan Zheng, Guofu Zhong, Xiaofei Zeng
Abstract
Abstract A highly efficient direct asymmetric allylic substitution (AAS) reaction of indolizine derivatives with allylic alcohols for accessing enantioenriched indolizine derivatives was realized by combining a chiral iridium complex catalyst with Lewis acid under mild reaction conditions, delivering various chiral allylation products in remarkably high yields and excellent enantioselectivities. This protocol distinguishes itself by availability of the starting materials, mild reaction conditions, broad substrate scope, high yields, excellent selectivity and easy scale‐up in a stereoselective manner, which provides a highly efficient protocol for chiral indolizines.