Synthesis and Biological Activity of Novel Zinc-Itraconazole Complexes in Protozoan Parasites and <i>Sporothrix</i> spp
José Aleixo de Azevedo-França, Renato Granado, Sara Teixeira de Macedo Silva, Gabrielle dos Santos-Silva, Sandra Mara Naressi Scapin, Luana Pereira Borba-Santos, Sônia Rozental, Wanderley de Souza, Érica S. Martins-Duarte, Emile Barrias, Juliany Cola Fernandes Rodrigues, Maribel Navarro
Abstract
The new complexes Zn(ITZ) 2 Cl 2 (1) and Zn(ITZ) 2 (OH) 2 (2) were synthetized by a reaction of itraconazole with their respective zinc salts under reflux. These Zn-ITZ complexes were characterized by elemental analyses, molar conductivity, mass spectrometry, 1 H and 13 C{ 1 H} nuclear magnetic resonance, and UV-vis and infrared spectroscopies. The antiparasitic and antifungal activity of Zn-ITZ complexes was evaluated against three protozoans of medical importance, namely, Leishmania amazonensis , Trypanosoma cruzi , and Toxoplasma gondii , and two fungi, namely, Sporothrix brasiliensis and Sporothrix schenckii .