Selective Synthesis of β-Ketonitriles via Catalytic Carbopalladation of Dinitriles
Zeng Ge, Jichao Liu, Yinlin Shao, Fangjun Zhang, Zhongyan Chen, Ningning Lv, Jiuxi Chen, Renhao Li
Abstract
A practical, convenient, and highly selective method of synthesizing β-ketonitriles from the Pd-catalyzed addition of organoboron reagents to dinitriles has been developed. This method provides excellent functional-group tolerance, a broad scope of substrates, and the convenience of using commercially available substrates. The method is expected to show further utility in future synthetic procedures.
Topics & Concepts
ChemistryReagentCombinatorial chemistryFunctional groupScope (computer science)CatalysisOrganic chemistryComputer sciencePolymerProgramming languageCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsOrganoboron and organosilicon chemistry