Spelling out the roles of individual nucleoporins in nuclear export of mRNA
Mark Tingey, Yichen Li, Wenlan Yu, Albert Young, Weidong Yang
Abstract
The Nuclear Pore Complex (NPC) represents a critical passage through the nuclear envelope for nuclear import and export that impacts nearly every cellular process at some level. Recent technological advances in the form of Auxin Inducible Degron (AID) strategies and Single-Point Edge-Excitation sub-Diffraction (SPEED) microscopy have enabled us to provide new insight into the distinct functions and roles of nuclear basket nucleoporins (Nups) upon nuclear docking and export for mRNAs. In this paper, we provide a review of our recent findings as well as an assessment of new techniques, updated models, and future perspectives in the studies of mRNA's nuclear export.
Topics & Concepts
NucleoporinSpellingNuclear export signalMessenger RNANuclear poreNuclear transportCell biologyBiologyComputational biologyGeneticsCell nucleusGeneNucleusLinguisticsPhilosophyNuclear Structure and FunctionRNA Research and SplicingRNA regulation and disease