Design and prediction of novel pyrazole derivatives as potential anti-cancer compounds based on 2D-QSAR study against PC-3, B16F10, K562, MDA-MB-231, A2780, ACHN and NUGC cancer cell lines
Fatima Ezzahra Bennani, Latifa Doudach, Khalid Karrouchi, Youssef El Rhayam, Christopher E. Rudd, M’hammed Ansar, My El Abbés Faouzi
Abstract
than the standard compounds.
Topics & Concepts
Quantitative structure–activity relationshipPyrazolePartial least squares regressionCancer cell linesCancerPrincipal component analysisComputational biologyChemistryComputer scienceCancer cellStereochemistryArtificial intelligenceBiologyMachine learningGeneticsComputational Drug Discovery MethodsSynthesis and biological activityClick Chemistry and Applications