Enantioselective Au( <scp>i</scp> )-catalyzed tandem reactions between 2-alkynyl enones and naphthols by the tethered counterion-directed catalysis strategy
Yunliang Yu, Nazarii Sabat, Meriem Daghmoum, Zhenhao Zhang, Pascal Retailleau, Gilles Frison, Angéla Marinetti, Xavier Guinchard
Abstract
.The TCDC approach enables tandem cycloisomerization/nucleophilic addition reactions of 2-alkynyl enones with naphthols, with good to excellent control of the regioselectivity and ees up to 99%, under optimized reaction conditions.
Topics & Concepts
ChemistryCycloisomerizationRegioselectivityCatalysisTandemNucleophileCombinatorial chemistryEnantioselective synthesisCounterionNucleophilic additionMesylateMedicinal chemistryOrganic chemistryIonComposite materialMaterials scienceCatalytic Alkyne ReactionsCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods