Insight into the practical models for prediciting the essential role of the cytochrome P450-mediated biotransformation in emodin-associated hepatotoxicity
Tingting Zhang, Xiaomei He, Lanlan Sun, Dong Wang, Shuya Zhang, Jianping Mao, Fengjiao Zhang
Topics & Concepts
EmodinMicrosomePharmacologyToxicityMetaboliteBiotransformationGlutathioneChemistryCytochrome P450HepatoprotectionHepatocyteIn vivoBiochemistryMedicineBiologyMetabolismIn vitroEnzymeBiotechnologyOrganic chemistryPhytochemistry and biological activity of medicinal plantsPharmacological Effects of Natural CompoundsChromatography in Natural Products