Ag@TiO<sub>2</sub> Nanocomposite as an Efficient Catalyst for Knoevenagel Condensation
Mostafa Sayed, Zhipeng Shi, Farzad Gholami, Pedram Fatehi, Ahmed I. A. Soliman
Abstract
in ethanol at 65 °C. The reaction scope was investigated for various aromatic and heterocyclic aldehydes with active methylene-containing compounds, and the isolated yields were significantly high. The reusability of the catalyst was investigated for up to five cycles, where an insignificant decrease in the catalyst's reactivity was observed. Also, the reaction could proceed in water as a solvent, and the isolated yield was 40%. Hence, this protocol features mild reaction conditions, a facile procedure, and clean reaction profiles.
Topics & Concepts
Knoevenagel condensationCatalysisMethyleneChemistryYield (engineering)Reactivity (psychology)SolventHeterogeneous catalysisCondensation reactionNanocompositeOrganic chemistryMaterials scienceNanotechnologyAlternative medicineMetallurgyPathologyMedicineMulticomponent Synthesis of HeterocyclesSynthesis and biological activityChemical Synthesis and Reactions