CD31 and D2-40 Contribute to Peritoneal Metastasis of Colorectal Cancer by Promoting Epithelial-Mesenchymal Transition
Xinqiang Zhu, Gang Zhou, Peng Ni, Xuetong Jiang, Hailong Huang, Jianqiang Wu, Xiaohong Shi, Xiaoling Jiang, Jianing Liu
Abstract
BACKGROUND/AIMS: Colorectal cancer (CRC) patients often exhibit peritoneal metastasis, which negatively impacts their prognosis. CD31 and D2-40 have recently been suggested to be predictors of breast cancer prognosis, but their role in colorectal peritoneal metastasis (CRPM) remains unknown. METHODS: , and peritoneal metastasis potential in a mouse model of CRPM were examined. RESULTS: . CONCLUSIONS: CD31 and D2-40 contribute to CRPM by promoting EMT and may serve as prognostic markers and therapeutic targets for CRC, particularly in patients with peritoneal metastasis.
Topics & Concepts
CD31MetastasisMedicineColorectal cancerEpithelial–mesenchymal transitionCancer researchIn vivoCancerPathologyOncologyInternal medicineAngiogenesisBiologyBiotechnologyCancer Cells and MetastasisGastric Cancer Management and OutcomesMetastasis and carcinoma case studies