MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential
Javaid Ahmad Wani, Sabhiya Majid, Zuha Imtiyaz, Muneeb U. Rehman, Rana M. Alsaffar, Naveed Nazir Shah, Sultan Alshehri, Mohammed M. Ghoneim, Syed Sarim Imam
Abstract
Lung cancer is the dominant emerging factor in cancer-related mortality around the globe. Therapeutic interventions for lung cancer are not up to par, mainly due to reoccurrence/relapse, chemoresistance, and late diagnosis. People are currently interested in miRNAs, which are small double-stranded (20-24 ribonucleotides) structures that regulate molecular targets (tumor suppressors, oncogenes) involved in tumorigeneses such as cell proliferation, apoptosis, metastasis, and angiogenesis via post-transcriptional regulation of mRNA. Many studies suggest the emerging role of miRNAs in lung cancer diagnostics, prognostics, and therapeutics. Therefore, it is necessary to intensely explore the miRNOME expression of lung tumors and the development of anti-cancer strategies. The current review focuses on the therapeutic, diagnostic, and prognostic potential of numerous miRNAs in lung cancer.