GLP-1 Receptor: A New Target for Sepsis
Fuxun Yang, Fan Zeng, Xiaoxiu Luo, Lei Yu, Jiajia Li, Sen Lu, Xiaobo Huang, Yunping Lan, Rongan Liu
Abstract
Patients with sepsis often exhibit hyperglycemia, which increases mortality. glucagon-like peptide-1 receptor agonists (GLP-1RAs) not only regulate blood glucose homeostasis but also improve organ dysfunction, regulate immunity, and control inflammation and other functions in patients with sepsis. Here, we review the possible application of GLP-1RAs in sepsis, to provide a new perspective for the clinical diagnosis and treatment of patients with sepsis complicated with stress hyperglycemia.
Topics & Concepts
SepsisMedicineGlucose homeostasisInflammationReceptorHomeostasisIntensive care medicineBioinformaticsImmunologyDiabetes mellitusInternal medicineBiologyEndocrinologyInsulin resistanceDiabetes Treatment and ManagementHyperglycemia and glycemic control in critically ill and hospitalized patientsDiabetes Management and Research