4-Octyl itaconate regulates immune balance by activating Nrf2 and negatively regulating PD-L1 in a mouse model of sepsis
Peng Zhang, Yaxin Wang, Wengchang Yang, Yuping Yin, Chengguo Li, Xianxiong Ma, Liang Shi, Ruidong Li, Kaixiong Tao
Abstract
Introduction: Sepsis is a major global health challenge with high mortality rates and no effective treatment. Recent studies have suggested that sepsis may be associated with immune system dysfunction. Itaconate may exert anti-inflammatory effects via Nrf2 signaling. Although Nrf2 regulates oxidative/exogenous stress responses and inhibits inflammatory responses, the mechanism via which Nrf2 regulates immune checkpoints in sepsis remains unclear.
Topics & Concepts
SepsisOxidative stressImmune systemInflammationImmunosuppressionProinflammatory cytokineImmunologyPharmacologyGlutathioneSignal transductionCytokineMedicineBiologyChemistryCell biologyBiochemistryInternal medicineEnzymeGenomics, phytochemicals, and oxidative stressMacrophage Migration Inhibitory FactorVitamin C and Antioxidants Research