Head-to-tail cyclization for the synthesis of naturally occurring cyclic peptides on organophosphorus small-molecular supports
Haidi Li, Junyou Li, Jie Chao, Zixin Zhang, Chuanguang Qin
Abstract
4,4′-bis(diphenylphosphinyloxyl) diphenyl ketoxime and 4-diphenyl phospholoxy benzyl alcohol were designed and prepared as supports for peptide synthesis. The total synthesis of cyclic peptides in a resin-free manner was successfully demonstrated.
Topics & Concepts
ChemistryCyclic peptidePeptideAlcoholCombinatorial chemistryBenzyl alcoholStereochemistryOrganic chemistryBiochemistryCatalysisChemical Synthesis and AnalysisCarbohydrate Chemistry and SynthesisClick Chemistry and Applications