Organo-photoredox catalyzed <i>gem</i>-difluoroallylation of ketone-derived dihydroquinazolinones <i>via</i> C(sp<sup>3</sup>)–C bond and C(sp<sup>3</sup>)–F bond cleavage
Yue Zhang, Yue Zhang, Tianshuai Zhu, Yuqian Lin, Xian Wei, Xinyu Xie, Ruofan Lin, Zhijie Zhang, Weiwei Fang, Jing‐Jing Zhang, Yue Zhang, Yue Zhang, Meng-Yang Hu, Lingchao Cai, Zhen Chen
Abstract
An organo-photoredox catalyzed defluorinative alkylation of ketone-derived dihydroquinazolinones with α-trifluoromethyl alkenes is described, providing a facile access to a diverse set of gem -difluoroalkenes.
Topics & Concepts
KetoneChemistryTrifluoromethylBond cleavageMedicinal chemistryTriple bondCatalysisCleavage (geology)AlkenePhotoredox catalysisStereochemistryDouble bondOrganic chemistryPhotocatalysisMaterials scienceFracture (geology)AlkylComposite materialFluorine in Organic Chemistry