A cerium oxide@metal–organic framework nanoenzyme as a tandem catalyst for enhanced photodynamic therapy
Jintong Liu, Lin Yao Ye, Wei Xiong, Tianrui Liu, Hong Yang, Jianping Lei
Abstract
An O2 self-evolving core-shell theranostic nanohybrid was developed by encapsulating a nanoenzyme cerium oxide (CeOx) in a metal-organic framework (MOF). The hybrid reveals a 9-fold higher apoptotic percentage than bare CeOx in a harsh hypoxic microenvironment through tandem homogenous catalysis. Simultaneously, the oxygen-promoted therapeutic efficiency was self-monitored by the hybrid with caspase-3 activation, paving the way for MOF-functionalized nanoenzymes in theranostics.
Topics & Concepts
TandemCerium oxideCatalysisCeriumOxidePhotodynamic therapyMetalChemistryInorganic chemistryMaterials scienceOrganic chemistryComposite materialNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisAdvanced Photocatalysis Techniques