Linker optimization of HEPT derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors: From S=O to CHOR
Qingqing Hao, Ling Xu, Christophe Pannecouque, Erik De Clercq, Fen‐Er Chen
Topics & Concepts
LinkerReverse transcriptaseChemistryStereochemistryEC50Nucleoside Reverse Transcriptase InhibitorHuman immunodeficiency virus (HIV)Reverse-transcriptase inhibitorNucleosideEnzymeMutantLead compoundIn vitroRNABiochemistryVirologyBiologyGeneComputer scienceOperating systemHIV/AIDS drug development and treatmentHIV Research and TreatmentPneumocystis jirovecii pneumonia detection and treatment