Design and Development of Small-Molecule Arylaldoxime/5-Nitroimidazole Hybrids as Potent Inhibitors of MARK4: A Promising Approach for Target-Based Cancer Therapy
Mudasir Nabi Peerzada, Parvez Κhan, Nashrah Sharif Khan, Fernando Avecilla, Shadab Miyan Siddiqui, Md. Imtaiyaz Hassan, Amir Azam
Abstract
for human serum albumin, which reflects its remarkable transportation and delivery properties to the target site via blood. The present study impedes that in the future, such compounds may stand as optimized pharmacological lead candidates in drug discovery for targeting cancer via MARK4 inhibition with a remarkable anticancer profile.
Topics & Concepts
KinaseChemistrySmall moleculeSerineBiochemistryDocking (animal)Cancer researchPharmacologyEnzymeBiologyMedicineNursingMelanoma and MAPK PathwaysComputational Drug Discovery MethodsSynthesis and biological activity