Metabolic reprogramming by ex vivo glutamine inhibition endows CAR-T cells with less-differentiated phenotype and persistent antitumor activity
Luyan Shen, Yefei Xiao, Chaoting Zhang, Shance Li, Xia Teng, Likun Cui, Ting Liu, Nan Wu, Zheming Lu
Topics & Concepts
Ex vivoGlutamineIn vivoBiologyCytotoxic T cellT cellCell biologyCellular differentiationCancer researchIn vitroBiochemistryImmune systemImmunologyGeneticsAmino acidGeneCAR-T cell therapy researchImmune Cell Function and InteractionViral Infectious Diseases and Gene Expression in Insects