Fiber scaffold bioartificial liver therapy relieves acute liver failure and extrahepatic organ injury in pigs
Jun Weng, Xu Han, Fanhong Zeng, Yue Zhang, Lei Feng, Lei Cai, Kangyan Liang, Shusong Liu, Li Shao, Gongbo Fu, Min Zeng, Yi Gao
Abstract
BAL treatment enhanced liver regeneration and alleviated the systemic inflammatory response and extrahepatic organ injury to prolong survival in the ALF model and has potential as a therapeutic approach for ALF patients.
Topics & Concepts
Bioartificial liver deviceMedicineLiver injuryOrgan dysfunctionHepatic encephalopathyLiver functionAcute kidney injuryPathologyGastroenterologyInternal medicineHepatocyteChemistryIn vitroSepsisBiochemistryCirrhosisLiver physiology and pathologyOrgan Transplantation Techniques and OutcomesLiver Disease and Transplantation