Role of the Extracellular Matrix in Alzheimer’s Disease
Yahan Sun, Sen Xu, Ming Jiang, Xia Liu, Liang Yang, Zhan‐Tao Bai, Qinghu Yang
Abstract
Alzheimer's disease (AD) is a neurodegenerative disease with complex pathological characteristics, whose etiology and pathogenesis are still unclear. Over the past few decades, the role of the extracellular matrix (ECM) has gained importance in neurodegenerative disease. In this review, we describe the role of the ECM in AD, focusing on the aspects of synaptic transmission, amyloid-β-plaque generation and degradation, Tau-protein production, oxidative-stress response, and inflammatory response. The function of ECM in the pathological process of AD will inform future research on the etiology and pathogenesis of AD.
Topics & Concepts
PathogenesisDiseaseExtracellular matrixPathologicalNeuroscienceOxidative stressEtiologyExtracellularAlzheimer's diseaseMedicineBiologyPathologyCell biologyInternal medicineAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsS100 Proteins and Annexins