MnO<sub>2</sub> coated nanotheranostic LDH for synergistic cascade chemo/chemodynamic cancer therapy under the guidance of MRI-targeted diagnosis
Bengao Zhu, Xuefei Lv, Mengmeng Zhang, Huiying Wang, Senbin Chen, Jintao Zhu
Abstract
nanomedicine integrating multiple treatment modalities and magnetic resonance imaging properties, causes persistent modulation of the TME and exhibits effective antitumor theranostic performance. Such a sophisticated nanomedicine design not only achieves improved CT/CDT antitumor efficiency, but also realizes the activatable magnetic resonance imaging. This strategy combines the merits of each treatment, significantly enhancing the anticancer efficacy, and is anticipated to display promising potentials in the clinical translation plans.
Topics & Concepts
CascadeCancer therapyChemistryCancerCancer researchComputational biologyBiologyMedicineInternal medicineChromatographyNanoplatforms for cancer theranosticsMetal-Organic Frameworks: Synthesis and ApplicationsLanthanide and Transition Metal Complexes