Promoting the activation of T cells with glycopolymer-modified dendritic cells by enhancing cell interactions
Liyin Yu, Ruyan Feng, Li‐Juan Zhu, Qing Hao, Jiacheng Chu, Yan Gu, Yan Luo, Zexin Zhang, Gaojian Chen, Hong Chen
Abstract
Dendritic cell (DC) modification to enhance antigen presentation is a valuable strategy in cancer immune therapy. Other than focusing on regulating interactions between DC and antigens, we intend to promote cell interactions between DC and T cell by cell surface engineering. T cell activation is greatly improved and generates higher tumor toxicity with the aid of the synthetic glycopolymer modified on the DC surface, although the glycopolymer alone shows no effect. The great promotion of DC-T cell attraction is revealed by cell image tracking in terms of both frequency and duration of contacts. Our findings provide a new method of T cell activation by these engineered "sweet DCs." This strategy is beneficial for developing more efficient DC-based vaccines.