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CHFR-mediated degradation of RNF126 confers sensitivity to PARP inhibitors in triple-negative breast cancer cells

Wenjing Wu, Jianli Zhao, Jianhong Xiao, Weijun Wu, Li‐Min Xie, Xiaojuan Xie, Chaoye Yang, Dong Yin, Kaishun Hu

2021Biochemical and Biophysical Research Communications10 citationsDOI

Topics & Concepts

Ubiquitin ligaseTriple-negative breast cancerUbiquitinCancer researchDNA damagePARP1Downregulation and upregulationPARP inhibitorDNA repairDNA ligaseBiologyPoly ADP ribose polymeraseCell biologyChemistryCancerBreast cancerBiochemistryDNAGeneticsGenePolymerasePARP inhibition in cancer therapyDNA Repair MechanismsUbiquitin and proteasome pathways
CHFR-mediated degradation of RNF126 confers sensitivity to PARP inhibitors in triple-negative breast cancer cells | Litcius