Catalytic asymmetric 1,4-type Friedel–Crafts (hetero)arylations of 1-azadienes: the highly enantioselective syntheses of chiral hetero-triarylmethanes
Chengjie Wang, Qiqiong Yang, Mei‐Xin Wang, Yun-Han Shang, Xinyu Tong, Yu‐Hua Deng, Zhihui Shao
Abstract
Strategies for achieving the direct catalytic asymmetric syntheses of benzofuran-containing hetero-triarylmethanes using a 1,4-type Friedel–Crafts (hetero)arylation reaction were developed.
Topics & Concepts
ChemistryFriedel–Crafts reactionEnantioselective synthesisCatalysisBenzofuranOrganic chemistryCombinatorial chemistrySynthesis of Indole DerivativesChemical synthesis and alkaloidsAxial and Atropisomeric Chirality Synthesis