Design, synthesis and biological assessment of acridine derivatives containing 1,3,4-thiadiazole moiety as novel selective acetylcholinesterase inhibitors
Safa Lotfi, Talat Rahmani, Maryam Hatami, Behjat Pouramiri, Esmat Tavakolinejad Kermani, Elham Rezvannejad, Mojtaba Mortazavi, Shahnaz Fathi Hafshejani, Nahid Askari, Nader Pourjamali, Mahboobeh Zahedifar
Topics & Concepts
ChemistryMoietyTacrineAcridineStereochemistryDocking (animal)AcetylcholinesteraseActive siteBinding siteDimedoneAromatic amineNon-competitive inhibitionEnzymeCombinatorial chemistryBiochemistryOrganic chemistryCatalysisNursingMedicineCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsSynthesis and biological activity