Association between Antibiotic Exposure and the Risk of Rash in Children with Infectious Mononucleosis: a Multicenter, Retrospective Cohort Study
Rui Zhang, Zhen Mao, Chang Xu, Wen Wang, Joey Sum-Wing Kwong, Minjie Xu, Yi Song, Tianyi Lv, Zhiyuan Teng, Ruifeng Zhong, Hui Liu, Yang Liu, Qin Wang, Ying Wang, Yuan Zhang, Shuya Chen, Xiuli Chai, Rui He, Wenyi Zheng, Jiaxing Zhang
Abstract
= 0.029). Of 92 overall rash cases, 43 were probably related to antibiotic exposure: two cases (4.08%) in the amoxicillin-treated group and 41 (8.15%) in the group treated with other antibiotics. Regression analysis indicated that the risk of rash induced by amoxicillin in IM children was similar to that induced by other penicillins (AOR, 1.12; 95% CI, ~0.13 to 9.67), cephalosporins (AOR, 2.45; 95% CI, ~0.43 to 14.02), or macrolides (AOR, 0.91; 95% CI, ~0.15 to 5.43). Antibiotic exposure may be associated with an increased risk of overall rash in IM children, but amoxicillin was not found to be associated with any increased risk of rash during IM compared to other antibiotics. We suggest that clinicians be vigilant against the occurrence of rash in IM children receiving antibiotic therapy, rather than indiscriminately avoiding prescribing amoxicillin.