PP1 promotes cyclin B destruction and the metaphase–anaphase transition by dephosphorylating CDC20
James Bancroft, James Holder, Zoë Geraghty, Tatiana Alfonso‐Pérez, Daniel Murphy, Francis A. Barr, Ulrike Grüneberg
Abstract
Cyclin B destruction is the crucial event triggering exit from mitosis. This study shows how PP1 promotes cyclin B destruction by removing inhibitory phosphorylation from the APC/C coactivator CDC20.
Topics & Concepts
BiologyCyclin BCell biologyCDC20Mitotic exitAnaphaseMetaphaseAnaphase-promoting complexCyclin ACyclin DMitosisCyclinCancer researchCell cycleGeneticsApoptosisGeneChromosomeMicrotubule and mitosis dynamicsCellular transport and secretionPhotosynthetic Processes and Mechanisms