A unified resource and configurable model of the synapse proteome and its role in disease
Oksana Sorokina, Colin Mclean, Mike D. R. Croning, Katharina F. Heil, Emilia Wysocka, Xin He, David C. Sterratt, Seth G. N. Grant, T. Ian Simpson, J. Douglas Armstrong
Abstract
Genes encoding synaptic proteins are highly associated with neuronal disorders many of which show clinical co-morbidity. We integrated 58 published synaptic proteomic datasets that describe over 8000 proteins and combined them with direct protein-protein interactions and functional metadata to build a network resource that reveals the shared and unique protein components that underpin multiple disorders. All the data are provided in a flexible and accessible format to encourage custom use.
Topics & Concepts
MetadataSynapseComputer scienceProteomeComputational biologyResource (disambiguation)Encoding (memory)NeuroscienceBioinformaticsBiologyWorld Wide WebComputer networkArtificial intelligenceBioinformatics and Genomic NetworksMachine Learning in BioinformaticsAdvanced Proteomics Techniques and Applications