Enzymology of standalone elongating ketosynthases
Aochiu Chen, Ziran Jiang, Michael D. Burkart
Abstract
, the complex mechanism of KSs continues to be unravelled, including recent understanding of gating motifs, KS-ACP interactions, substrate recognition and delivery, and roles in unsaturated fatty acid biosynthesis. In this review, we summarize the latest studies, primarily conducted through structural biology and molecular probe design, that shed light on the emerging enzymology of standalone elongating KSs.
Topics & Concepts
PolyketideEnzymeBiosynthesisChemistryCarbon fibersFatty acidBiochemistryAcyl carrier proteinStereochemistryMaterials scienceComposite materialComposite numberMicrobial Metabolic Engineering and BioproductionMicrobial Natural Products and BiosynthesisEnzyme Catalysis and Immobilization