A Single Amino Acid at Residue 188 of the Hexon Protein Is Responsible for the Pathogenicity of the Emerging Novel Virus Fowl Adenovirus 4
Yu Zhang, Aijing Liu, Yanan Wang, Hongyu Cui, Yulong Gao, Xiaole Qi, Changjun Liu, Yanping Zhang, Kai Li, Li Gao, Qing Pan, Xiaomei Wang
Abstract
, whereas the wild-type strain was not. Further, the rR188I mutant strain provided complete protection against FAdV-4 challenge. Our results provide a molecular basis of the increased virulence of novel FAdV-4. We propose that the rR188I mutant is a potential live attenuated vaccine against HHS and a new vaccine vector for HHS-combined vaccines.
Topics & Concepts
BiologyVirulenceVirologyFowlRecombinant DNAVirusPathogenicityPathogenesisStrain (injury)MicrobiologyGeneGeneticsImmunologyAnatomyPaleontologyVirus-based gene therapy researchViral gastroenteritis research and epidemiologyAnimal Virus Infections Studies