Euphohyrisnoids A and B, Two Highly Rearranged Lathyrane Diterpenoids from <i>Euphorbia lathyris</i>
Dong Huang, Yue-Hua Pan, Fang-Yu Yuan, Wei Li, Xue‐Long Yan, Ming-Feng Zou, Gui‐Hua Tang, Sheng Yin
Abstract
Euphohyrisnoids A (1) and B (2), two highly rearranged lathyrane diterpenoids featuring a unique tetracyclo[10.2.2.01,10.03,7]cetane and tricyclo[8.4.1.03,7]pentadecane skeleton, respectively, were isolated from the seeds of Euphorbia lathyris. Their structures were determined by detailed spectroscopic analysis and were further confirmed by single-crystal X-ray diffraction. 1 significantly inhibited adipogenesis in 3T3-L1 adipocytes by retarding cell differentiation at the early stage.
Topics & Concepts
ChemistryEuphorbiaPentadecaneStereochemistryEuphorbiaceaeAdipogenesisBotanyBiochemistryBiologyAdipose tissueBioactive Natural Diterpenoids ResearchBiological Activity of Diterpenoids and BiflavonoidsPlant-based Medicinal Research