Rh(<scp>iii</scp>)-catalyzed C–H activation/annulation of <i>N</i>-carbamoylindoles with CF<sub>3</sub>-imidoyl sulfoxonium ylides for the divergent synthesis of trifluoromethyl-substituted (dihydro)pyrimidoindolones
Yubo Duan, Shu‐Ning Lu, Zuguang Yang, Zhengkai Chen, Xiao‐Feng Wu
Abstract
We have developed a Rh( iii )-catalyzed C–H activation/chemodivergent annulation of N -carbamoylindoles with TFISYs, allowing facile access to a variety of trifluoromethyl-substituted (dihydro)pyrimidoindolones with high efficiency. Solvents play a critical role in the selectivity of the reaction.
Topics & Concepts
AnnulationChemistryTrifluoromethylCatalysisSelectivityCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryAlkylCatalytic C–H Functionalization MethodsFluorine in Organic ChemistryCyclopropane Reaction Mechanisms