Clinical Practice Guidelines for Pre-Analytical Procedures of Plasma Epidermal Growth Factor Receptor Variant Testing
Saeam Shin, Hye In Woo, Jong‐Won Kim, Yoonjung Kim, Kyung‐A Lee
Abstract
Standardization of cell-free DNA (cfDNA) testing processes is necessary to obtain clinically reliable results. The pre-analytical phase of cfDNA testing greatly influences the results because of the low proportion and stability of circulating tumor DNA (ctDNA). In this review, we provide evidence-based clinical practice guidelines for pre-analytical phase procedures of plasma epidermal growth factor receptor gene (EGFR) variant testing. Specific recommendations for pre-analytical procedures were proposed based on evidence from the literature and our experimental data. Standardization of pre-analytical procedures can improve the analytical performance of cfDNA testing.
Topics & Concepts
StandardizationEpidermal growth factor receptorClinical PracticeMedicineComputational biologyComputer scienceOncologyInternal medicineBiologyReceptorFamily medicineOperating systemCancer Genomics and DiagnosticsLymphoma Diagnosis and TreatmentChronic Lymphocytic Leukemia Research