Cytosolic DNA sensor cGAS plays an essential pathogenetic role in pressure overload-induced heart failure
Dan Hu, Yu-Xia Cui, Manyan Wu, Long Li, Lina Su, Zheng Lian, Hong Chen
Abstract
In this study, we first revealed a novel role of cGAS in the regulation of pathological cardiac remodeling and dysfunction upon pressure overload. We found that the cGAS/STING pathway was activated during pressure overload. Moreover, we also demonstrated that inhibition of the cGAS/STING pathway alleviated pathological cardiac remodeling and downregulated the early inflammatory response during pressure overload-induced HF. Together, these findings will provide a new therapeutic target for HF.
Topics & Concepts
Pressure overloadCytosolCell biologyDNAHeart failureDNA damageChemistryBiologyGeneticsMedicineCardiologyBiochemistryCardiac hypertrophyEnzymeinterferon and immune responsesEndoplasmic Reticulum Stress and DiseaseUbiquitin and proteasome pathways