Cleavage of Abasic Sites in DNA by an Aminoquinoxaline Compound: Augmented Cytotoxicity and DNA Damage in Combination with an Anticancer Drug Chlorambucil in Human Colorectal Carcinoma Cells
Chandra Sova Mandi, Tridib Mahata, Dipendu Patra, Jeet Chakraborty, Achyut Bora, Ritesh Pal, Sanjay Dutta
Abstract
/M phases, eventually leading to apoptotic cell death in HCT-116 cells. Hence, the outcome of this study provides a definitive approach that will help optimize the therapeutic applications for targeting the abasic site in cancer cells.
Topics & Concepts
AP siteDNA damageChemistryDNATopoisomeraseBase excision repairCytotoxicityCancer researchCancer cellChlorambucilMolecular biologyBiochemistryBiologyCancerIn vitroChemotherapyGeneticsCyclophosphamideSynthesis and Biological EvaluationCancer therapeutics and mechanismsDNA and Nucleic Acid Chemistry