Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin
Delia Susan‐Resiga, Emmanuelle Girard, Rachid Essalmani, Anna Roubtsova, Jadwiga Marcinkiewicz, Rabeb Mouna Derbali, Alexandra Evagelidis, Jae Hyun Byun, Paul Lebeau, Richard C. Austin, Nabil G. Seidah
Abstract
↓ motif into a secreted form, likely resulting in a loss of function on LDLR. Altogether, we demonstrate that LDLR is the first example of a liver-receptor ligand of ASGR1. We conclude that silencing of ASGR1 and PCSK9 may lead to higher LDL uptake by hepatocytes, thereby providing a novel approach to further reduce LDL cholesterol levels.
Topics & Concepts
LDL receptorAsialoglycoprotein receptorPCSK9BiologyFurinKexinMolecular biologyReceptorProprotein convertaseChemistryBiochemistryCholesterolLipoproteinHepatocyteIn vitroEnzymeLipoproteins and Cardiovascular HealthSignaling Pathways in DiseaseDiabetes, Cardiovascular Risks, and Lipoproteins