Novel A-<i>seco</i>-nortriterpenoids from <i>Ganoderma cochlear</i> inhibiting Tau pathology by activating AMPK-ULK1-mediated autophagy
Rongcan Luo, Yi Luo, Da-Shuang Fang, Yong‐Gang Yao, Ming‐Hua Qiu, Xing‐Rong Peng
Abstract
Ten structurally diverse A-seco-nortriterpenoids were isolated from the fruiting bodies of Ganoderma cochlear . Compounds 1–4 significantly inhibited tau pathology by inducing autophagy mediated by AMPK-ULK1 pathway.
Topics & Concepts
AutophagyAMPKChemistryULK1Cell biologyGanodermaGanoderma lucidumBiochemistryProtein kinase AKinaseBiologyApoptosisFood scienceFungal Biology and ApplicationsPlant Stress Responses and TolerancePolysaccharides and Plant Cell Walls