Steatosis induced by nonylphenol in HepG2 cells and the intervention effect of curcumin
Dandan Shan, Jinming Wang, Qiannan Di, Qianqian Jiang, Qian Xu
Abstract
-acetyl-L-cysteine (NAC) can reverse these phenomena. In addition, our study found that curcumin effectively ameliorated the effects of NP-induced steatosis. Our study indicates that NP can induce steatosis in HepG2 cells, and may be implicated in inhibiting the ROS-dependent AMPK/mTOR pathway, and that curcumin ameliorates the NAFLD-like changes induced by NP in HepG2 cells.
Topics & Concepts
SteatosisLipogenesisAMPKCurcuminPI3K/AKT/mTOR pathwayChemistryFatty liverOxidative stressLipid dropletLipid metabolismEndocrinologyInternal medicineBiochemistrySignal transductionBiologyMedicineProtein kinase APhosphorylationDiseaseLiver Disease Diagnosis and TreatmentAdipose Tissue and MetabolismCurcumin's Biomedical Applications