A manganese-phenolic network platform amplifying STING activation to potentiate MRI guided cancer chemo-/chemodynamic/immune therapy
Xinrui Pang, Chaoping Fu, Junbin Chen, Miao Su, Ruili Wei, Ye Wang, Wanxian Lin, Xinhua Wei, Xinqing Jiang, Xianzhu Yang, Huikang Yang, Junxia Wang, Ruimeng Yang
Abstract
-weighted magnetic resonance imaging (MRI). Moreover, TMPD combined with immune checkpoint blockade (ICB) immunotherapy significantly inhibited tumor growth and lung metastasis. Collectively, these findings indicate that TMPD has great potential in activating robust innate and adaptive immunity for MRI guided cancer chemo-/chemodynamic/immune therapy.
Topics & Concepts
Immunogenic cell deathStingCancer researchImmunotherapyChemistryImmune systemInnate immune systemStimulator of interferon genesImmune checkpointIntracellularCancer immunotherapyMedicineImmunologyBiochemistryEngineeringAerospace engineeringinterferon and immune responsesNanoplatforms for cancer theranosticsImmune cells in cancer