Design, synthesis and antitumor activity of a novel FGFR2-selective degrader to overcome resistance of the FGFR2V564F gatekeeper mutation based on a pan-FGFR inhibitor
Zuli Hu, Qiangsheng Zhang, Zulong Li, Hongling Yang, Xin Chen, Qi Zhang, Tianqiong Yang, Xiaojie He, Qiang Feng, Jun He, Luoting Yu
Topics & Concepts
ChemistryMutationCancer researchFibroblast growth factor receptorFibroblast growth factorPharmacologyBiochemistryGeneReceptorBiologyMedicineFibroblast Growth Factor ResearchProtein Degradation and InhibitorsKruppel-like factors research