Facile synthesis of lactoferrin conjugated ultra small large pore silica nanoparticles for the treatment of glioblastoma
Taskeen Iqbal Janjua, Aria Ahmed-Cox, Anand Kumar Meka, Friederike M. Mansfeld, Helen Forgham, Rosa Mistica C. Ignacio, Yuxue Cao, Joshua A. McCarroll, Roberta Mazzieri, Maria Kavallaris, Amirali Popat
Abstract
49.16 respectively). Moreover, this USLP-Lf based delivery platform improved the efficacy of doxorubicin-mediated apoptosis of GBM cells in both 2D and 3D models. Collectively, our new nano-platform has the potential to overcome both the BBB and BTB to treat GBM more effectively.
Topics & Concepts
LactoferrinNanomedicineBlood–brain barrierDoxorubicinNanocarriersNanoparticleIn vitroGlioblastomaConjugateCancer researchConjugated systemMaterials scienceNanotechnologyChemistryChemotherapyMedicineInternal medicineBiochemistryMathematicsComposite materialCentral nervous systemPolymerMathematical analysisGraphene and Nanomaterials ApplicationsAdvancements in Battery MaterialsNanoparticle-Based Drug Delivery