Inter-axonal molecular crosstalk via Lumican proteoglycan sculpts murine cervical corticospinal innervation by distinct subpopulations
Yasuhiro Itoh, Vibhu Sahni, Sara J. Shnider, Holly McKee, Jeffrey D. Macklis
Abstract
subpopulations. This inter-axonal molecular crosstalk between CSN subpopulations controls murine corticospinal circuitry refinement and forelimb dexterity. Such crosstalk is generalizable beyond the corticospinal system for evolutionary incorporation of new neuron populations into preexisting circuitry.
Topics & Concepts
LumicanBiologyNeuroscienceForelimbSpinal cordBrainstemAnatomyAxonCrosstalkAxon guidanceProteoglycanOpticsDecorinCartilagePhysicsNeurogenesis and neuroplasticity mechanismsAxon Guidance and Neuronal SignalingNerve injury and regeneration