Metal-free synthesis of difluoro/trifluoromethyl carbinol-containing chromones <i>via</i> tandem cyclization of <i>o</i>-hydroxyaryl enaminones
Longhui Wu, Xia Liu, Zhao-Wen Liu, Zhi-Xi Chen, Xin-Lei Fu, Kai Yang
Abstract
-hydroxyphenyl enaminones at room temperature. This protocol provides a facile and efficient approach to access diverse difluoro/trifluoromethylated carbinols in good to excellent yields. In addition, gram-scale and synthetic derivatization experiments have also been performed.
Topics & Concepts
ChemistryTrifluoromethylTandemMetalMedicinal chemistryOrganic chemistryCombinatorial chemistryStereochemistryAlkylMaterials scienceComposite materialFluorine in Organic ChemistrySynthesis and Characterization of PyrrolesSynthesis of Organic Compounds