Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models
Yao‐Xin Lin, Yi Wang, Jianxun Ding, Aiping Jiang, Jie Wang, Mian Yu, Sara Blake, Shuaishuai Liu, Charles J. Bieberich, Omid C. Farokhzad, Lin Mei, Hao Wang, Jinjun Shi
Abstract
The restoration of tumor suppressor PTEN by synthetic mRNA nanoparticles sensitizes Pten -null or mutated tumors to immune checkpoint blockade therapy.
Topics & Concepts
PTENSuppressorCancer researchBlockadeImmune checkpointImmunityImmune systemMedicineBiologyImmunologyImmunotherapyCancerPI3K/AKT/mTOR pathwayCell biologyReceptorInternal medicineSignal transductionPI3K/AKT/mTOR signaling in cancerCancer Mechanisms and TherapyVascular Tumors and Angiosarcomas