Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation
Jessica Guerra, Ana Luiza Chaves Valadão, Dimitriοs Vlachakis, Katarzyna Polak, Isabelle K. Vila, Clara Taffoni, Thaneas Prabakaran, Andrew S. Marriott, Renata Kaczmarek, Armel Houël, Baptiste Auzemery, Stephanie Déjardin, Pierre Boudinot, Barbara Nawrot, Nigel J. Jones, Søren R. Paludan, Sofia Kossida, Christelle Langevin, Nadine Laguette
Abstract
The LysRS-Ap 4 A axis impairs cGAS-STING pathway activation, delaying nucleic acid-driven innate immune responses.
Topics & Concepts
StingInnate immune systemNucleic acidInflammationTransfer RNACell biologyImmune systemHemolymphBiologyChemistryBiochemistryImmunologyRNAGeneEngineeringAerospace engineeringinterferon and immune responsesViral Infections and VectorsInflammasome and immune disorders