Recent Advances in C(sp<sup>3</sup>)–C(sp<sup>3</sup>) Cross-Coupling Chemistry: A Dominant Performance of Nickel Catalysts
Ramagonolla Kranthikumar
Abstract
The formation of a new C–C bond at sp3-hybridized centers is highly desirable, as it opens up a unique, unexplored chemical space. The revolutionary discoveries in this field meet the longstanding challenge of forming stereocontrolled C–C bonds and provide rapid access to C(sp3)-rich drug molecules. The new and improved catalytic systems have enabled the creative design of challenging transformations. The latest advancements in nickel catalysis are particularly attractive and have shown excellent catalytic performance in this field. The progress that has been made toward C(sp3)–C(sp3) bond formation (traditional and cross-electrophile couplings) in the past decade is highlighted in this review.
Topics & Concepts
ChemistryCatalysisNickelElectrophileCombinatorial chemistryChemical spaceMoleculeNanotechnologyComputational chemistryDrug discoveryOrganic chemistryMaterials scienceBiochemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis