Rh(III)-Catalyzed Chemodivergent Coupling of <i>N</i>-Phenoxyacetamides and Alkylidenecyclopropanes via C–H Activation
Guiqing Xu, Qi Chen, Fen Wu, Dachang Bai, Junbiao Chang, Xingwei Li
Abstract
-phenoxyacetamides and chemodivergent coupling to alkylidenecyclopropanes (ACPs) have been accomplished. With the assistance of the ring strain of ACPs, the coupling can be transannulative or nonannulative, delivering 3-ethylidenedihydrobenzofurans or dienes, respectively, under different reaction conditions, and the selectivity is mainly solvent-controlled. All of the reactions proceeded under mild conditions with a good substrate scope and excellent chemo- and diastereoselectivity.
Topics & Concepts
ChemistryCatalysisSelectivitySubstrate (aquarium)Coupling (piping)SolventMedicinal chemistryScope (computer science)Ring (chemistry)Combinatorial chemistryStereochemistryOrganic chemistryMetallurgyComputer scienceProgramming languageMaterials scienceOceanographyGeologyCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsCatalytic Alkyne Reactions