Neutrophils are shaped by the tumor microenvironment: novel possibilities for targeting neutrophils in cancer
Carlos Silvestre-Roig, Lydia Kalafati, Triantafyllos Chavakis
Abstract
In a recent paper published in Science , Ng et al. provide seminal insights into the process through which neutrophils are reprogrammed by the tumor environment, leading to a convergent transition from different neutrophil states towards a unique end-stage differentiated pro-tumor phenotype. 1 These findings have major translational implications as they provide potential neutrophil-related targets for tumor immunotherapy.
Topics & Concepts
Tumor microenvironmentCancerCancer researchMedicineImmunologyBiologyPathologyTumor cellsInternal medicineImmune cells in cancerNeutrophil, Myeloperoxidase and Oxidative MechanismsImmune responses and vaccinations